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Description:
The Insulin Receptor (IR) is synthesized as a single polypeptide, which is subsequently cleaved to generate an extracellular α chain and a transmembrane and intracellular β chain, tethered together by disulfide bonds. The β chain has multiple tyrosine phosphorylation sites, including three autophosphorylation sites at its activation…
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Description:
IP-10 (interferon-gamma inducible protein 10 kDa), also known as CXCL10, was originally identified as an IFN--inducible gene. It is induced in a variety of cells in response to IFN-and LPS. In contrast to other CXC chemokines, IP-10 has no chemotactic activity for neutrophils. It is a pleiotropic molecule that appears to target…
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Specification:96testDescription:
Parathyroid hormone (iPTH intact parathyroid hormone) is an 84 amino acid polypeptide produced by the parathyroid gland with its biological activity residing in the N-terminal region of the peptide. PTH plays an important role in maintaining the concentration of ionized calcium within the limits needed to achieve…
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Description:
IL-1ra binds to the IL-1 receptor Type II with considerably lower affinity than that shown by IL-1β. This makes sense teleologically in that two mechanisms designed to inhibit the actions of IL-1βdo not compete with each other. Cells known to produce IL-1ra include monocytes, neutrophils, macrophages and fibroblasts. Cytokines known…
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Description:
The receptor for IL22 (also termed CRF29 and IL TIFR1 chain) is a new member of the class II cytokine receptor family. IL22 Receptor forms a complex with IL10 Receptor beta chain and mediates IL22 signaling. IL22 and its receptor activate the JAK/STAT signaling pathway. IL22 Receptor is expressed in normal liver and kidney and their…
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Description:
Leukotriene B4 (LTB4) is a potent pro-inflammatory molecule that belongs to a family of eicosanoid lipid mediators. It is synthesized from arachidonic acid that is generated from nuclear membrane phospholipid. In general, and upon cell activation, phospholipase A2 is directed to the nuclear membrane. Here, it generates arachidonic…
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Description:
Inhibin A is a dimer of alpha and beta A subunits, inhibin B is a dimer of alpha and beta B subunits. Inhibin belongs to the transforming growth factor-β superfamily.In women, FSH stimulates the secretion of inhibin from the granulosa cells of the ovarian follicles in ovary. In turn, inhibin suppresses FSH.Inhibin secretion is…
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Description:
Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that has been shown to play a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential to the development and survival of NK cells and CD8 T-cells. IL-15 activates Jak/Stat pathways by signaling through a heterotrimeric receptor. Two of the…
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Description:
Interleukin 12 (IL-12) is an interleukin that is naturally produced by macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer, and…
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Description:
IL-12 p70 ELISA reagent set (with or without high-affinity binding microwell plates) contains the necessary reagents, buffers and diluents for performing quantitative enzyme linked immunosorbent assays (ELISA). This IL-12 p70 ELISA reagent set specifically measures the bioactive, heterodimeric form of IL-12, p70, without…
Description: The Insulin Receptor (IR) is synthesized as a single polypeptide, which is subsequently cleaved to generate an extracellular α chain and a transmembrane and intracellular β chain, tethered together by disulfide bonds. The β chain has multiple tyrosine phosphorylation sites, including three autophosphorylation sites at its activation…
Description: IP-10 (interferon-gamma inducible protein 10 kDa), also known as CXCL10, was originally identified as an IFN--inducible gene. It is induced in a variety of cells in response to IFN-and LPS. In contrast to other CXC chemokines, IP-10 has no chemotactic activity for neutrophils. It is a pleiotropic molecule that appears to target…
Specification:96testDescription: Parathyroid hormone (iPTH intact parathyroid hormone) is an 84 amino acid polypeptide produced by the parathyroid gland with its biological activity residing in the N-terminal region of the peptide. PTH plays an important role in maintaining the concentration of ionized calcium within the limits needed to achieve…
Description: IL-1ra binds to the IL-1 receptor Type II with considerably lower affinity than that shown by IL-1β. This makes sense teleologically in that two mechanisms designed to inhibit the actions of IL-1βdo not compete with each other. Cells known to produce IL-1ra include monocytes, neutrophils, macrophages and fibroblasts. Cytokines known…
Description: The receptor for IL22 (also termed CRF29 and IL TIFR1 chain) is a new member of the class II cytokine receptor family. IL22 Receptor forms a complex with IL10 Receptor beta chain and mediates IL22 signaling. IL22 and its receptor activate the JAK/STAT signaling pathway. IL22 Receptor is expressed in normal liver and kidney and their…
Description: Leukotriene B4 (LTB4) is a potent pro-inflammatory molecule that belongs to a family of eicosanoid lipid mediators. It is synthesized from arachidonic acid that is generated from nuclear membrane phospholipid. In general, and upon cell activation, phospholipase A2 is directed to the nuclear membrane. Here, it generates arachidonic…
Description: Inhibin A is a dimer of alpha and beta A subunits, inhibin B is a dimer of alpha and beta B subunits. Inhibin belongs to the transforming growth factor-β superfamily.In women, FSH stimulates the secretion of inhibin from the granulosa cells of the ovarian follicles in ovary. In turn, inhibin suppresses FSH.Inhibin secretion is…
Description: Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that has been shown to play a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential to the development and survival of NK cells and CD8 T-cells. IL-15 activates Jak/Stat pathways by signaling through a heterotrimeric receptor. Two of the…
Description: Interleukin 12 (IL-12) is an interleukin that is naturally produced by macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer, and…
Description: IL-12 p70 ELISA reagent set (with or without high-affinity binding microwell plates) contains the necessary reagents, buffers and diluents for performing quantitative enzyme linked immunosorbent assays (ELISA). This IL-12 p70 ELISA reagent set specifically measures the bioactive, heterodimeric form of IL-12, p70, without…
